Apoptosis

Apoptosis

Each antibody domain can bind to a MAGE-MHC-1 peptide complex on the tumor cell. This fixates (cross-links) up to six target molecules on the surface of tumor cells which results in a process called programmed cell death (apoptosis).

 

 

Apoptosis is an active and programmed physiological process for eliminating superfluous, altered or malignant cells. Apoptosis is characterized by shrinkage of cells, segmentation of the nucleus, condensation and cleavage of DNA into domain-sized fragments, and is then generally followed by further degradation and removal of the apoptotic cell.